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Microwave-Induced Nucleophilic [(18)F]Fluorination on Aromatic Rings: Synthesis and Effect of Halogen on [(18)F]Fluoride Substitution of meta-Halo (F, Cl, Br, I)-Benzonitrile Derivatives
The meta-halo-3-methylbenzonitrile derivatives (-F, -Cl, -Br, -I) were synthesized as model compounds to study reactivity towards aromatic nucleophilic substitution. A single-mode microwave system was incorporated into a commercial radiochemical synthetic module for F-18 labeling. Labeling yields of...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2553010/ https://ncbi.nlm.nih.gov/pubmed/18417350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apradiso.2008.03.003 |
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