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Construction of a large phage–displayed human antibody domain library with a scaffold based on a newly identified highly soluble, stable heavy chain variable domain
Currently, almost all FDA approved therapeutic antibodies and the vast majority of those in clinical trials are full-size antibodies mostly in IgG1 format of about 150 kDa size. A fundamental problem for such large molecules is their poor penetration into tissues (e.g. solid tumors) and poor or abse...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2551765/ https://ncbi.nlm.nih.gov/pubmed/18687338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.07.054 |
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