Recombinant human lactoferrin expressed in glycoengineered Pichia pastoris: effect of terminal N-acetylneuraminic acid on in vitro secondary humoral immune response

Traditional production of therapeutic glycoproteins relies on mammalian cell culture technology. Glycoproteins produced by mammalian cells invariably display N-glycan heterogeneity resulting in a mixture of glycoforms the composition of which varies from production batch to production batch. However...

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Hlavní autoři: Choi, Byung-Kwon, Actor, Jeffrey K., Rios, Sandra, d'Anjou, Marc, Stadheim, Terrance A., Warburton, Shannon, Giaccone, Erin, Cukan, Michael, Li, Huijuan, Kull, Angela, Sharkey, Nathan, Gollnick, Paul, Kocięba, Maja, Artym, Jolanta, Zimecki, Michal, Kruzel, Marian L., Wildt, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2551750/
https://ncbi.nlm.nih.gov/pubmed/18365311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10719-008-9123-y
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