Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction

OBJECTIVE—Visceral obesity and elevated plasma free fatty acids are predisposing factors for type 2 diabetes. Chronic exposure to these lipids is detrimental for pancreatic β-cells, resulting in reduced insulin content, defective insulin secretion, and apoptosis. We investigated the involvement in t...

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Hlavní autoři: Lovis, Pascal, Roggli, Elodie, Laybutt, D. Ross, Gattesco, Sonia, Yang, Jiang-Yan, Widmann, Christian, Abderrahmani, Amar, Regazzi, Romano
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2008
Témata:
Islet Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2551683/
https://ncbi.nlm.nih.gov/pubmed/18633110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1252
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