A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes

OBJECTIVE—Zinc transporter eight (SLC30A8) is a major target of autoimmunity in human type 1A diabetes and is implicated in type 2 diabetes in genome-wide association studies. The type 2 diabetes nonsynonymous single nucleotide polymorphism (SNP) affecting aa(325) lies within the region of highest Z...

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Main Authors: Wenzlau, Janet M., Liu, Yu, Yu, Liping, Moua, Ong, Fowler, Kimberly T., Rangasamy, Sampathkumar, Walters, Jay, Eisenbarth, George S., Davidson, Howard W., Hutton, John C.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2008
Fag:
Immunology and Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2551679/
https://ncbi.nlm.nih.gov/pubmed/18591387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0522
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