Genetic variability of herpes simplex virus: development of a pathogenic variant during passaging of a nonpathogenic herpes simplex virus type 1 virus strain in mouse brain.

Herpes simplex virus type 1 ANG (HSV-1 ANG) is originally nonpathogenic for inbred mice upon intraperitoneal intravenous, or intravaginal inoculation. In contrast, mice died of encephalitis within 4 to 5 days after intracerebral inoculation with this strain. HSV-1 ANG was serially passaged in mouse...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Kaerner, H C, Schröder, C H, Ott-Hartmann, A, Kümel, G, Kirchner, H
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1983
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC255095/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6298472/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.46.1.83-93.1983
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