Genetic variability of herpes simplex virus: development of a pathogenic variant during passaging of a nonpathogenic herpes simplex virus type 1 virus strain in mouse brain.

Herpes simplex virus type 1 ANG (HSV-1 ANG) is originally nonpathogenic for inbred mice upon intraperitoneal intravenous, or intravaginal inoculation. In contrast, mice died of encephalitis within 4 to 5 days after intracerebral inoculation with this strain. HSV-1 ANG was serially passaged in mouse...

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Autores principales: Kaerner, H C, Schröder, C H, Ott-Hartmann, A, Kümel, G, Kirchner, H
Formato: Artigo
Lenguaje:Inglês
Publicado: 1983
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC255095/
https://ncbi.nlm.nih.gov/pubmed/6298472
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