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Overexpression of Spry1 in Chondrocytes Causes Attenuated FGFR Ubiquitination and Sustained ERK Activation Resulting in Chondrodysplasia

The FGF signaling pathway plays essential roles in endochondral ossification by regulating osteoblast proliferation and differentiation, chondrocyte proliferation, hypertrophy, and apoptosis. FGF signaling is controlled by the complementary action of both positive and negative regulators of the sign...

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Main Authors: Yang, Xuehui, Harkins, Lauren K., Zubanova, Olga, Harrington, Anne, Kovalenko, Dmitry, Nadeau, Robert J., Chen, Pei-Yu, Toher, Jessica L., Lindner, Volkhard, Liaw, Lucy, Friesel, Robert
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2548288/
https://ncbi.nlm.nih.gov/pubmed/18582454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.05.555
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