Spry1 and Spry4 Differentially Regulate Human Aortic Smooth Muscle Cell Phenotype via Akt/FoxO/Myocardin Signaling

BACKGROUND: Changes in the vascular smooth muscle cell (VSMC) contractile phenotype occur in pathological states such as restenosis and atherosclerosis. Multiple cytokines, signaling through receptor tyrosine kinases (RTK) and PI3K/Akt and MAPK/ERK pathways, regulate these phenotypic transitions. Th...

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Detalhes bibliográficos
Main Authors: Yang, Xuehui, Gong, Yan, Tang, Yuefeng, Li, Hongfang, He, Qing, Gower, Lindsey, Liaw, Lucy, Friesel, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598808/
https://ncbi.nlm.nih.gov/pubmed/23554919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058746
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