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Focal Adhesion Targeting: The Critical Determinant of FAK Regulation and Substrate Phosphorylation

The focal adhesion kinase (FAK) is discretely localized to focal adhesions via its C-terminal focal adhesion–targeting (FAT) sequence. FAK is regulated by integrin-dependent cell adhesion and can regulate tyrosine phosphorylation of downstream substrates, like paxillin. By the use of a mutational st...

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Main Authors: Shen, Yu, Schaller, Michael D.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 1999
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC25482/
https://ncbi.nlm.nih.gov/pubmed/10436008
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