Focal Adhesion Targeting: The Critical Determinant of FAK Regulation and Substrate Phosphorylation
The focal adhesion kinase (FAK) is discretely localized to focal adhesions via its C-terminal focal adhesion–targeting (FAT) sequence. FAK is regulated by integrin-dependent cell adhesion and can regulate tyrosine phosphorylation of downstream substrates, like paxillin. By the use of a mutational st...
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| Опубликовано в:: | Mol Biol Cell |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Cell Biology
1999
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25482/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10436008/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.10.8.2507 |
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