A Quantitative Model of Thermal Stabilization and Destabilization of Proteins by Ligands

Equilibrium binding ligands usually increase protein thermal stability by an amount proportional to the concentration and affinity of the ligand. High-throughput screening for the discovery of drug-like compounds uses an assay based on thermal stabilization. The mathematical description of this stab...

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Hlavní autoři: Cimmperman, Piotras, Baranauskienė, Lina, Jachimovičiūtė, Simona, Jachno, Jelena, Torresan, Jolanta, Michailovienė, Vilma, Matulienė, Jurgita, Sereikaitė, Jolanta, Bumelis, Vladas, Matulis, Daumantas
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2008
Témata:
Biophysical Theory and Modeling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547457/
https://ncbi.nlm.nih.gov/pubmed/18599640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.134973
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