A Quantitative Model of Thermal Stabilization and Destabilization of Proteins by Ligands

Equilibrium binding ligands usually increase protein thermal stability by an amount proportional to the concentration and affinity of the ligand. High-throughput screening for the discovery of drug-like compounds uses an assay based on thermal stabilization. The mathematical description of this stab...

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Detalhes bibliográficos
Main Authors: Cimmperman, Piotras, Baranauskienė, Lina, Jachimovičiūtė, Simona, Jachno, Jelena, Torresan, Jolanta, Michailovienė, Vilma, Matulienė, Jurgita, Sereikaitė, Jolanta, Bumelis, Vladas, Matulis, Daumantas
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2008
Assuntos:
Biophysical Theory and Modeling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547457/
https://ncbi.nlm.nih.gov/pubmed/18599640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.134973
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