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The Structure of the Amyloid-β Peptide High-Affinity Copper II Binding Site in Alzheimer Disease
Neurodegeneration observed in Alzheimer disease (AD) is believed to be related to the toxicity from reactive oxygen species (ROS) produced in the brain by the amyloid-β (Aβ) protein bound primarily to copper ions. The evidence for an oxidative stress role of Aβ-Cu redox chemistry is still incomplete...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Biophysical Society
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2547438/ https://ncbi.nlm.nih.gov/pubmed/18599641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.134429 |
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