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The Structure of the Amyloid-β Peptide High-Affinity Copper II Binding Site in Alzheimer Disease

Neurodegeneration observed in Alzheimer disease (AD) is believed to be related to the toxicity from reactive oxygen species (ROS) produced in the brain by the amyloid-β (Aβ) protein bound primarily to copper ions. The evidence for an oxidative stress role of Aβ-Cu redox chemistry is still incomplete...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Streltsov, Victor A., Titmuss, Stephen J., Epa, V. Chandana, Barnham, Kevin J., Masters, Colin L., Varghese, Joseph N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547438/
https://ncbi.nlm.nih.gov/pubmed/18599641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.134429
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