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Stereospecificity of Ketoreductase Domains of the 6-Deoxyerythronolide B Synthase

6-Deoxyerythronolide B synthase (DEBS) is a modular polyketide synthase (PKS) responsible for the biosynthesis of 6-dEB (1), the parent aglycone of the broad spectrum macrolide antibiotic erythromycin. Individual DEBS modules, which contain the catalytic domains necessary for each step of polyketide...

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Sonraí Bibleagrafaíochta
Main Authors: Castonguay, Roselyne, He, Weiguo, Chen, Alice Y., Khosla, Chaitan, Cane, David E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547127/
https://ncbi.nlm.nih.gov/pubmed/17918944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0753290
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