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Stereospecificity of Ketoreductase Domains of the 6-Deoxyerythronolide B Synthase

6-Deoxyerythronolide B synthase (DEBS) is a modular polyketide synthase (PKS) responsible for the biosynthesis of 6-dEB (1), the parent aglycone of the broad spectrum macrolide antibiotic erythromycin. Individual DEBS modules, which contain the catalytic domains necessary for each step of polyketide...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Castonguay, Roselyne, He, Weiguo, Chen, Alice Y., Khosla, Chaitan, Cane, David E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547127/
https://ncbi.nlm.nih.gov/pubmed/17918944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0753290
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