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Apoptosis and Autophagy Induction in Mammalian Cells by Small Interfering RNA Knockdown of mRNA Capping Enzymes

Addition of a 5′ cap to RNA polymerase II transcripts, the first step of pre-mRNA processing in eukaryotes from yeasts to mammals, is catalyzed by the sequential action of RNA triphosphatase, guanylyltransferase, and (guanine-N-7)methyltransferase. The effects of knockdown of these capping enzymes i...

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Detalhes bibliográficos
Main Authors: Chu, Chun, Shatkin, Aaron J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547012/
https://ncbi.nlm.nih.gov/pubmed/18678651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00021-08
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