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Human mRNA Cap Methyltransferase: Alternative Nuclear Localization Signal Motifs Ensure Nuclear Localization Required for Viability

A characteristic feature of gene expression in eukaryotes is the addition of a 5′-terminal 7-methylguanine cap (m7GpppN) to nascent pre-mRNAs in the nucleus catalyzed by capping enzyme and cap methyltransferase. Small interfering RNA (siRNA) knockdown of cap methyltransferase in HeLa cells resulted...

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Xehetasun bibliografikoak
Egile Nagusiak: Shafer, Beth, Chu, Chun, Shatkin, Aaron J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2005
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061643/
https://ncbi.nlm.nih.gov/pubmed/15767670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.7.2644-2649.2005
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