Human Parainfluenza Virus Type 1 C Proteins Are Nonessential Proteins That Inhibit the Host Interferon and Apoptotic Responses and Are Required for Efficient Replication in Nonhuman Primates

Recombinant human parainfluenza virus type 1 (rHPIV1) was modified to create rHPIV1-P(C−), a virus in which expression of the C proteins (C′, C, Y1, and Y2) was silenced without affecting the amino acid sequence of the P protein. Infectious rHPIV1-P(C−) was readily recovered from cDNA, indicating th...

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Bibliografiska uppgifter
Huvudupphovsmän: Bartlett, Emmalene J., Cruz, Ann-Marie, Esker, Janice, Castaño, Adam, Schomacker, Henrick, Surman, Sonja R., Hennessey, Margaret, Boonyaratanakornkit, Jim, Pickles, Raymond J., Collins, Peter L., Murphy, Brian R., Schmidt, Alexander C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
Ämnen:
Cellular Response to Infection
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546903/
https://ncbi.nlm.nih.gov/pubmed/18614629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00853-08
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