The C Proteins of Human Parainfluenza Virus Type 1 Block IFN Signaling by Binding and Retaining Stat1 in Perinuclear Aggregates at the Late Endosome

Interferons (IFNs) play a crucial role in the antiviral immune response. Whereas the C proteins of wild-type human parainfluenza virus type 1 (WT HPIV1) inhibit both IFN-β induction and signaling, a HPIV1 mutant encoding a single amino acid substitution (F170S) in the C proteins is unable to block e...

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Detalhes bibliográficos
Main Authors: Schomacker, Henrick, Hebner, Rebecca M., Boonyaratanakornkit, Jim, Surman, Sonja, Amaro-Carambot, Emerito, Collins, Peter L., Schmidt, Alexander C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280236/
https://ncbi.nlm.nih.gov/pubmed/22355301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028382
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