The C Proteins of Human Parainfluenza Virus Type 1 Limit Double-Stranded RNA Accumulation That Would Otherwise Trigger Activation of MDA5 and Protein Kinase R

Human parainfluenza virus type 1 (HPIV1) is an important respiratory pathogen in young children, the immunocompromised, and the elderly. We found that infection with wild-type (WT) HPIV1 suppressed the innate immune response in human airway epithelial cells by preventing not only phosphorylation of...

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Hlavní autoři: Boonyaratanakornkit, Jim, Bartlett, Emmalene, Schomacker, Henrick, Surman, Sonja, Akira, Shizuo, Bae, Yong-Soo, Collins, Peter, Murphy, Brian, Schmidt, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2011
Témata:
Cellular Response to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028907/
https://ncbi.nlm.nih.gov/pubmed/21123378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01297-10
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