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The CRL4(Cdt2) ubiquitin ligase targets the degradation of p21(Cip1) to control replication licensing
The faithful replication of genomic DNA is crucial for maintaining genome stability. In eukaryotes, DNA rereplication is prevented by the temporal regulation of replication licensing. Replication-licensing factors are required to form prereplicative complexes during G1 phase, but are inactivated in...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2546690/ https://ncbi.nlm.nih.gov/pubmed/18794348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1703708 |
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