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The efficient syntheses of 5′-deoxy-5′-fluoro -guanosine and –inosine

[Image: see text] Substitution of oxygen with a weak hydrogen bond acceptor such as fluorine provides a single-atom modification that can have grave effects on the chemical and medicinal properties of nucleoside analogs. To that end, we present a simple and high yielding method for the novel synthes...

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Autors principals: Spitale, Robert C., Heller, Moriah G., Pelly, Amanda J., Wedekind, Joseph E.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546599/
https://ncbi.nlm.nih.gov/pubmed/17902696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo7015778
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