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Identification of an Imino Group Indispensable for Cleavage by a Small Ribozyme
[Image: see text] The hairpin ribozyme is a small, non-coding (nc)RNA that catalyzes a site-specific phosphodiester bond cleavage reaction. Prior biochemical and structural analyses pinpointed the amidine moiety of base Ade38 as a key functional group in catalysis, however base changes designed to p...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692201/ https://ncbi.nlm.nih.gov/pubmed/19354216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja900450h |
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