Chemoprevention of 7, 12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of a dual inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 tyrosine kinases

Oral cancer is a common neoplasm worldwide with tobacco and alcohol being the major etiological factors contributing to its pathogenesis. Epidermal growth factor receptor (EGFR) and ErbB2 are known to be involved in the development of oral cancer with the former up-regulated in up to 90% human cases...

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Main Authors: Sun, Zheng, Sood, Sandeep, Li, Ning, Yang, Peiying, Newman, Robert A., Yang, Chung S., Chen, Xiaoxin
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546572/
https://ncbi.nlm.nih.gov/pubmed/17936675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oraloncology.2007.08.006
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