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Phosphate Is Essential for Inhibition of the Mitochondrial Permeability Transition Pore by Cyclosporin A and by Cyclophilin D Ablation

Energized mouse liver mitochondria displayed the same calcium retention capacity (a sensitive measure of the propensity of the permeability transition pore (PTP) to open) irrespective of whether phosphate, arsenate, or vanadate was the permeating anion. Unexpectedly, however, phosphate was specifica...

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Main Authors: Basso, Emy, Petronilli, Valeria, Forte, Michael A., Bernardi, Paolo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546556/
https://ncbi.nlm.nih.gov/pubmed/18684715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C800132200
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