Multiple Membrane-Cytoplasmic Domain Contacts in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mediate Regulation of Channel Gating

The cystic fibrosis transmembrane conductance regulator (CFTR) is a unique ATP-binding cassette (ABC) ion channel mutated in patients with cystic fibrosis. The most common mutation, deletion of phenylalanine 508 (ΔF508) and many other disease-associated mutations occur in the nucleotide binding doma...

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Bibliographische Detailangaben
Hauptverfasser: He, Lihua, Aleksandrov, Andrei A., Serohijos, Adrian W. R., Hegedüs, Tamás, Aleksandrov, Luba A., Cui, Liying, Dokholyan, Nikolay V., Riordan, John R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Membrane Transport, Structure, Function, and Biogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546535/
https://ncbi.nlm.nih.gov/pubmed/18658148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803894200
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