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Substrates and Non-transportable Analogues Induce Structural Rearrangements at the Extracellular Entrance of the Glial Glutamate Transporter GLT-1/EAAT2

To explore rearrangements of the reentrant loop HP2 relative to transmembrane domains (TMs) 7 and 8 during transport by the glial glutamate transporter GLT-1/EAAT2, cysteine pairs were introduced at the extracellular ends of these structural elements. The pairs were introduced around 10–15Å “above”...

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Detalhes bibliográficos
Main Authors: Qu, Shaogang, Kanner, Baruch I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546532/
https://ncbi.nlm.nih.gov/pubmed/18658151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802401200
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