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High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma

The childhood cancer neuroblastoma arises in the developing sympathetic nervous system and is a genotypically and phenotypically heterogeneous disease. Prognostic markers of poor survival probability include amplification of the MYCN oncogene and an undifferentiated morphology. Whereas these feature...

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Detalhes bibliográficos
Main Authors: Fredlund, Erik, Ringnér, Markus, Maris, John M., Påhlman, Sven
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544584/
https://ncbi.nlm.nih.gov/pubmed/18780787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804455105
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