Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice

Hashimoto's thyroiditis (HT) is associated with HLA, but the associated allele is still controversial. We hypothesized that specific HLA-DR pocket-sequence variants are associated with HT and that similar variants in the murine I-E locus (homologous to HLA-DR) predispose to experimental autoimm...

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Hlavní autoři: Menconi, Francesca, Monti, Maria C., Greenberg, David A., Oashi, Taiji, Osman, Roman, Davies, Terry F., Ban, Yoshiyuki, Jacobson, Eric M., Concepcion, Erlinda S., Li, Cheuk Wun, Tomer, Yaron
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544574/
https://ncbi.nlm.nih.gov/pubmed/18779568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806584105
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