Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A(2b) agonists by protein kinase C

PKG activator 8-(4-chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate (CPT) at reperfusion protects ischemic hearts, but the mechanism is unknown. We recently proposed that in preconditioned hearts PKC lowers the threshold for adenosine to initiate signaling from low-affinity A(2b) receptors dur...

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Hlavní autoři: Kuno, Atsushi, Solenkova, Nataliya V., Solodushko, Victoriya, Dost, Turhan, Liu, Yanping, Yang, Xi-Ming, Cohen, Michael V., Downey, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544479/
https://ncbi.nlm.nih.gov/pubmed/18660452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00209.2008
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