Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A(2b) agonists by protein kinase C

PKG activator 8-(4-chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate (CPT) at reperfusion protects ischemic hearts, but the mechanism is unknown. We recently proposed that in preconditioned hearts PKC lowers the threshold for adenosine to initiate signaling from low-affinity A(2b) receptors dur...

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Detalhes bibliográficos
Main Authors: Kuno, Atsushi, Solenkova, Nataliya V., Solodushko, Victoriya, Dost, Turhan, Liu, Yanping, Yang, Xi-Ming, Cohen, Michael V., Downey, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544479/
https://ncbi.nlm.nih.gov/pubmed/18660452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00209.2008
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