Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure

Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. Here, we report that cardiac-specific knockout of Dicer, a gene encoding a RNase III endonuclease essential for microRNA...

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Autors principals: Chen, Jian-Fu, Murchison, Elizabeth P., Tang, Ruhang, Callis, Thomas E., Tatsuguchi, Mariko, Deng, Zhongliang, Rojas, Mauricio, Hammond, Scott M., Schneider, Michael D., Selzman, Craig H., Meissner, Gerhard, Patterson, Cam, Hannon, Gregory J., Wang, Da-Zhi
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542870/
https://ncbi.nlm.nih.gov/pubmed/18256189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710228105
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