Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure

Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. Here, we report that cardiac-specific knockout of Dicer, a gene encoding a RNase III endonuclease essential for microRNA...

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Библиографические подробности
Главные авторы: Chen, Jian-Fu, Murchison, Elizabeth P., Tang, Ruhang, Callis, Thomas E., Tatsuguchi, Mariko, Deng, Zhongliang, Rojas, Mauricio, Hammond, Scott M., Schneider, Michael D., Selzman, Craig H., Meissner, Gerhard, Patterson, Cam, Hannon, Gregory J., Wang, Da-Zhi
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2008
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542870/
https://ncbi.nlm.nih.gov/pubmed/18256189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710228105
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