Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure

Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. Here, we report that cardiac-specific knockout of Dicer, a gene encoding a RNase III endonuclease essential for microRNA...

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Detaylı Bibliyografya
Asıl Yazarlar: Chen, Jian-Fu, Murchison, Elizabeth P., Tang, Ruhang, Callis, Thomas E., Tatsuguchi, Mariko, Deng, Zhongliang, Rojas, Mauricio, Hammond, Scott M., Schneider, Michael D., Selzman, Craig H., Meissner, Gerhard, Patterson, Cam, Hannon, Gregory J., Wang, Da-Zhi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542870/
https://ncbi.nlm.nih.gov/pubmed/18256189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710228105
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