Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure

Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. Here, we report that cardiac-specific knockout of Dicer, a gene encoding a RNase III endonuclease essential for microRNA...

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Detalhes bibliográficos
Main Authors: Chen, Jian-Fu, Murchison, Elizabeth P., Tang, Ruhang, Callis, Thomas E., Tatsuguchi, Mariko, Deng, Zhongliang, Rojas, Mauricio, Hammond, Scott M., Schneider, Michael D., Selzman, Craig H., Meissner, Gerhard, Patterson, Cam, Hannon, Gregory J., Wang, Da-Zhi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542870/
https://ncbi.nlm.nih.gov/pubmed/18256189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710228105
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