Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure

Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. Here, we report that cardiac-specific knockout of Dicer, a gene encoding a RNase III endonuclease essential for microRNA...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Chen, Jian-Fu, Murchison, Elizabeth P., Tang, Ruhang, Callis, Thomas E., Tatsuguchi, Mariko, Deng, Zhongliang, Rojas, Mauricio, Hammond, Scott M., Schneider, Michael D., Selzman, Craig H., Meissner, Gerhard, Patterson, Cam, Hannon, Gregory J., Wang, Da-Zhi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2008
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542870/
https://ncbi.nlm.nih.gov/pubmed/18256189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710228105
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