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Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
PTEN is a tumor suppressor gene but whether cancer can develop in all PTEN-deficient cells is not known. In T cell-specific PTEN-deficient (tPTEN(−/−)) mice, which suffer from mature T cell lymphomas, we found that premalignancy, as defined by elevated AKT and senescence pathways, starts in immature...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2538875/ https://ncbi.nlm.nih.gov/pubmed/18250301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712059105 |
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