Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

PTEN is a tumor suppressor gene mutated in many human cancers, and its expression is reduced or absent in almost half of hepatoma patients. We used the Cre-loxP system to generate a hepatocyte-specific null mutation of Pten in mice (AlbCrePten(flox/flox) mice). AlbCrePten(flox/flox) mice showed mass...

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Main Authors: Horie, Yasuo, Suzuki, Akira, Kataoka, Ei, Sasaki, Takehiko, Hamada, Koichi, Sasaki, Junko, Mizuno, Katsunori, Hasegawa, Go, Kishimoto, Hiroyuki, Iizuka, Masahiro, Naito, Makoto, Enomoto, Katsuhiko, Watanabe, Sumio, Mak, Tak Wah, Nakano, Toru
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC420505/
https://ncbi.nlm.nih.gov/pubmed/15199412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420513
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