Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve

Peripheral sensory neurons respond to axon injury by activating an importin-dependent retrograde signaling mechanism. How is this mechanism regulated? Here we show that Ran GTPase and its associated effectors RanBP1 and RanGAP regulate the formation of importin signaling complexes in injured axons....

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Main Authors: Yudin, Dmitry, Hanz, Shlomit, Yoo, Soonmoon, Iavnilovitch, Elena, Willis, Dianna, Gradus, Tal, Vuppalanchi, Deepika, Segal-Ruder, Yael, Ben-Yaakov, Keren, Hieda, Miki, Yoneda, Yoshihiro, Twiss, Jeffery L., Fainzilber, Mike
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538677/
https://ncbi.nlm.nih.gov/pubmed/18667152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.05.029
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