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Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation
Here, we analyse the RanGTPase system and its coupling to receptor-mediated nuclear transport. Our simulations predict nuclear RanGTP levels in HeLa cells to be very sensitive towards the cellular energy charge and to exceed the cytoplasmic concentration ≈1000-fold. The steepness of the RanGTP gradi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150346/ https://ncbi.nlm.nih.gov/pubmed/12606574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg113 |
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