Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation

Here, we analyse the RanGTPase system and its coupling to receptor-mediated nuclear transport. Our simulations predict nuclear RanGTP levels in HeLa cells to be very sensitive towards the cellular energy charge and to exceed the cytoplasmic concentration ≈1000-fold. The steepness of the RanGTP gradi...

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Pubblicato in:	EMBO J
Autori principali:	Görlich, Dirk, Seewald, Michael J., Ribbeck, Katharina
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2003
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150346/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12606574/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg113
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