Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation
Here, we analyse the RanGTPase system and its coupling to receptor-mediated nuclear transport. Our simulations predict nuclear RanGTP levels in HeLa cells to be very sensitive towards the cellular energy charge and to exceed the cytoplasmic concentration ≈1000-fold. The steepness of the RanGTP gradi...
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| Publicat a: | EMBO J |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150346/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12606574/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg113 |
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