An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo

We demonstrated recently that P8A-CCL2, a monomeric variant of the chemokine CCL2/MCP-1, is unable to induce cellular recruitment in vivo, despite full activity in vitro. Here, we show that this variant is able to inhibit CCL2 and thioglycollate-mediated recruitment of leukocytes into the peritoneal...

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Autori principali: Handel, Tracy M., Johnson, Zoë, Rodrigues, David H., dos Santos, Adriana C., Cirillo, Rocco, Muzio, Valeria, Riva, Simona, Mack, Matthias, Déruaz, Maud, Borlat, Frédéric, Vitte, Pierre-Alain, Wells, Timothy N. C., Teixeira, Mauro M., Proudfoot, Amanda E. I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Society for Leukocyte Biology 2008
Soggetti:
Extracellular Mediators and Effector Molecules
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538597/
https://ncbi.nlm.nih.gov/pubmed/18662971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0108061
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