Cisplatin Cytotoxicity of Auditory Cells Requires Secretions of Proinflammatory Cytokines via Activation of ERK and NF-κB

The ototoxicity of cisplatin, a widely used chemotherapeutic agent, involves a number of mechanisms, including perturbation of redox status, increase in lipid peroxidation, and formation of DNA adducts. In this study, we demonstrate that cisplatin increased the early immediate release and de novo sy...

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Hauptverfasser: So, Hongseob, Kim, HyungJin, Lee, Jeong-Han, Park, Channy, Kim, Yunha, Kim, Eunsook, Kim, Jin-Kyung, Yun, Ki-Jung, Lee, Kang-Min, Lee, Haa-Yung, Moon, Sung-Kyun, Lim, David J., Park, Raekil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538433/
https://ncbi.nlm.nih.gov/pubmed/17516123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10162-007-0084-9
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