Different uptake of gentamicin through TRPV1 and TRPV4 channels determines cochlear hair cell vulnerability

Hair cells at the base of the cochlea appear to be more susceptible to damage by the aminoglycoside gentamicin than those at the apex. However, the mechanism of base-to-apex gradient ototoxicity by gentamicin remains to be elucidated. We report here that gentamicin caused rodent cochlear hair cell d...

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Detalhes bibliográficos
Main Authors: Lee, Jeong-Han, Park, Channy, Kim, Se-Jin, Kim, Hyung-Jin, Oh, Gi-Su, Shen, AiHua, So, Hong-Seob, Park, Raekil
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641395/
https://ncbi.nlm.nih.gov/pubmed/23470714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2013.25
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