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Asymmetric Usage of Antagonist Charged Residues Drives Interleukin-5 Receptor Recruitment but is Insufficient for Receptor Activation
The cyclic peptide AF17121 (VDECWRIIASHTWFCAEE) is a library-derived antagonist for human Interleukin-5 receptor α (IL5Rα). We have previously demonstrated that AF17121 mimics Interleukin-5 (IL5) by binding in a region of IL5Rα that overlaps the IL5 binding epitope. In the present study, in order to...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2538410/ https://ncbi.nlm.nih.gov/pubmed/16430207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0518038 |
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