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Neurons Lacking Iron Regulatory Protein-2 Are Highly Resistant to the Toxicity of Hemoglobin

The effect of iron regulatory protein-2 (IRP2) on ferritin expression and neuronal vulnerability to hemoglobin was assessed in primary cortical cell cultures prepared from wild-type and IRP2 knockout mice. Baseline levels of H and L-ferritin subunits were significantly increased in IRP2 knockout neu...

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Bibliografiska uppgifter
Huvudupphovsmän: Regan, Raymond F., Chen, Mai, Li, Zhi, Zhang, Xuefeng, Benvenisti-Zarom, Luna, Chen-Roetling, Jing
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2537465/
https://ncbi.nlm.nih.gov/pubmed/18571425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.04.008
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