Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling

Although production of reactive oxygen species (ROS) such as superoxide (O(2)(·−)) has been implicated in chronic hypoxia-induced pulmonary hypertension (PH) and pulmonary vascular remodeling, the transcription factors and gene targets through which ROS exert their effects have not been completely i...

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Main Authors: Nozik-Grayck, Eva, Suliman, Hagir B., Majka, Susan, Albietz, Joseph, Van Rheen, Zachary, Roush, Kevin, Stenmark, Kurt R.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2008
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536799/
https://ncbi.nlm.nih.gov/pubmed/18599502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90293.2008
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