Inhibition of tristetraprolin deadenylation by poly(A) binding protein

Tristetraprolin (TTP) is the prototype for a family of RNA binding proteins that bind the tumor necrosis factor (TNF) messenger RNA AU-rich element (ARE), causing deadenylation of the TNF poly(A) tail, RNA decay, and silencing of TNF protein production. Using mass spectrometry sequencing we identifi...

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Detalhes bibliográficos
Main Authors: Rowlett, Robert M., Chrestensen, Carol A., Schroeder, Melanie J., Harp, Mary G., Pelo, Jared W., Shabanowitz, Jeffery, DeRose, Robert, Hunt, Donald F., Sturgill, Thomas W., Worthington, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Inflammation/Immunity/Mediators
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536786/
https://ncbi.nlm.nih.gov/pubmed/18467502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00508.2007
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