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Tristetraprolin and Its Family Members Can Promote the Cell-Free Deadenylation of AU-Rich Element-Containing mRNAs by Poly(A) Ribonuclease

Eukaryotic mRNA stability can be influenced by AU-rich elements (AREs) within mRNA primary sequences. Tristetraprolin (TTP) is a CCCH tandem zinc finger protein that binds to ARE-containing transcripts and destabilizes them, apparently by first promoting the removal of their poly(A) tails. We develo...

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Udgivet i:Mol Cell Biol
Principais autores: Lai, Wi S., Kennington, Elizabeth A., Blackshear, Perry J.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2003
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155217/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12748283/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.11.3798-3812.2003
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