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Tristetraprolin and Its Family Members Can Promote the Cell-Free Deadenylation of AU-Rich Element-Containing mRNAs by Poly(A) Ribonuclease

Eukaryotic mRNA stability can be influenced by AU-rich elements (AREs) within mRNA primary sequences. Tristetraprolin (TTP) is a CCCH tandem zinc finger protein that binds to ARE-containing transcripts and destabilizes them, apparently by first promoting the removal of their poly(A) tails. We develo...

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Detalhes bibliográficos
Main Authors: Lai, Wi S., Kennington, Elizabeth A., Blackshear, Perry J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155217/
https://ncbi.nlm.nih.gov/pubmed/12748283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.11.3798-3812.2003
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