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Bilayer mechanical properties regulate transmembrane helix mobility and enzymatic state of CD39

CD39 can exist in at least two distinct functional states depending on the presence and intact membrane integration of its two transmembrane helices. In native membranes, the transmembrane helices undergo dynamic rotational motions that are required for enzymatic activity and are regulated by substr...

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Autors principals: Grinthal, Alison, Guidotti, Guido
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536646/
https://ncbi.nlm.nih.gov/pubmed/17198399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061052p
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