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Design, Synthesis and Evaluation of Bisubstrate Analog Inhibitors of Cholera Toxin
Bisubstrate analog inhibitors in which a nicotinamide mimic is attached to a series of structurally diversified guanidines (arginine mimics) were synthesized and evaluated for inhibition of cholera toxin. The mechanism-based bisubstrate inhibitors were up to 1400-fold more potent than the natural su...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2536626/ https://ncbi.nlm.nih.gov/pubmed/18515100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.05.049 |
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